pentobarbital will lower the level or impact of atazanavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.
Barbiturates can induce hepatic microsomal enzymes resulting in improved metabolism and lowered anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); sufferers stabilized on anticoagulant therapy may well call for dosage changes if barbiturates are included to or withdrawn from their dosage program
pentobarbital will lower the level or effect of ethotoin by influencing hepatic enzyme CYP2C9/10 metabolism. Use Warning/Observe.
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pentobarbital will lower the level or effect of etravirine by impacting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Observe.
pentobarbital will reduce the level or result of levoketoconazole by impacting hepatic/intestinal read more enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.
Psychological, tolerance and Actual physical dependence may perhaps occur with continued use; patients with psychological dependence on barbiturates might build a Bodily dependence on barbiturates by rising or reducing the dosage interval devoid of consulting a medical professional
pentobarbital will reduce the level or outcome of aprepitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will minimize the extent or effect of stiripentol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. If struggling to avoid coadministration of stiripentol with potent CYP3A4 inducers, improve stiripentol dose.
pentobarbital will minimize the level or effect of glecaprevir/pibrentasvir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the level or effect of imatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.
pentobarbital will lower the level or influence of dapsone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unidentified.
pentobarbital will decrease the extent or influence of vardenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will lower the level or outcome of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is actually a sensitive CYP3A4 substrate. Coadministration with powerful or moderate CYP3A4 inducers is contraindicated.